2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N11507
    Tibesaikosaponin V 2319668-87-4 98%
    Tibesaikosaponin V (TKV) is a triterpene diglycoside, which can be isolated from the methanol extract of the roots of Bupleurum chinense DC.. Tibesaikosaponin V inhibits lipid accumulation and triacylglycerol content occurred without cytotoxicity to adipocytes. Tibesaikosaponin V suppresses the mRNA expression of nuclear transcription factors, such as peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer binding protein α (C/EBPα). Tibesaikosaponin V inhibits 3T3-L1 preadipocyte differentiation. Tibesaikosaponin V can be used fro research of obesity and its associated metabolic disorders.
    Tibesaikosaponin V
  • HY-N11512
    α-Glucosidase-IN-24 60354-05-4 98%
    α-Glucosidase-IN-24 (Compound 13) is an α-Glucosidase inhibitor with an IC50 of 451 μM. α-Glucosidase-IN-24 can be isolated from Swertia kouitchensis.
    α-Glucosidase-IN-24
  • HY-N11530
    Kouitchenside G 1444411-75-9 98%
    Kouitchenside G is a natural product that can be isolated from Swertia kouitchensis. Kouitchenside G inhibits α-Glucosidase with an IC50 of 956 μM.
    Kouitchenside G
  • HY-N11551
    Salvifaricin 87321-87-7 98%
    Salvifaricin is an orally active diterpenoid compound that can be isolated from Salvia leucantha Cav. and Salvia hispanica L.. Salvifaricin significantly reduces fasting blood glucose and serum triglyceride (TG) levels, and has anti-diabetic effect.
    Salvifaricin
  • HY-N11582
    Prodenialure A 16725-53-4
    Prodenialure A ((Z)-9-Tetradecenyl acetate) is an ester product.
    Prodenialure A
  • HY-N11598
    α-GLU 59920-31-9
    α-GLU stands for α-glucosidase. α-GLU hydrolyzes starch and disaccharides via targeting to terminal, non-reducing (1→4)-linked α-D-glucose residues to produce α-glucose. α-GLU is substrate selective.
    α-GLU
  • HY-N11602
    Deoxycholic acid 3-sulfate 67030-48-2 98%
    Deoxycholic acid 3-sulfate is a sulfated metabolite of deoxycholic acid, belonging to the sulfate ester form of secondary bile acids. The proportion of Deoxycholic acid 3-sulfate in serum from both healthy states and cholestatic states is below the limit of detection.
    Deoxycholic acid 3-sulfate
  • HY-N11604
    1-(1(Z)-Hexadecenyl)-2-palmitoleoyl-sn-glycero-3-phosphocholine 204983-72-2 98%
    1-(1(Z)-Hexadecenyl)-2-palmitoleoyl-sn-glycero-3-phosphocholine [PC (P-16:0/16:1 (9Z))] is a phosphatidylcholine that can be utilized for liposome preparation and serves as a marker in metabolomics research.
    1-(1(Z)-Hexadecenyl)-2-palmitoleoyl-sn-glycero-3-phosphocholine
  • HY-N11639
    Ganoderic acid Df 1352033-73-8 98%
    Ganoderic acid Df is a lanostane-type triterpenoid, that can be isolated from the fruiting body of Ganoderma lucidum. Ganoderic acid Df potently inhibits aldose reductase, with an IC50 of 22.8 ± 0.6 μM.
    Ganoderic acid Df
  • HY-N11660
    weak Hepatoprotective agent-1 1807808-90-7 98%
    weak Hepatoprotective agent-1 (Compound 11) is a natural product that can be isolated from the fruits of Arctium lappa L.. weak Hepatoprotective agent-1 exhibits weak hepatoprotective activities at a concentration of 10 μM.
    weak Hepatoprotective agent-1
  • HY-N11721
    5-Hydroxyaloin A 138373-23-6 98%
    5-Hydroxyaloin A is a polyphenolic antioxidant agent. 5-Hydroxyaloin A forms hydrogen bonding interactions at lipase’s active site and SOD’s active site with low binding energy. 5-Hydroxyaloin A inhibits microsomal lipid peroxidation induced by ferrous-cysteine, reducing malondialdehyde production. 5-Hydroxyaloin A can be used for the research of obesity.
    5-Hydroxyaloin A
  • HY-N11723
    Catenarin 476-46-0 98%
    Catenarin, an anthraquinone compound, inhibits CCR5- and CXCR4-mediated chemotaxis. Catenarin reduces the phosphorylation of mitogen-activated protein kinases (p38 and JNK) and their upstream kinases (MKK6 and MKK7), and calcium mobilization. Catenarin shows anti-inflammatory effect and suppresses leukocyte migration in the diabetes. Catenarin exhibits significant inhibitory effects against Gram-positive bacteria. Catenarin prevents type 1 diabetes (T1D) in nonobese diabetic mice[1][2].
    Catenarin
  • HY-N11728
    2,7"-Phloroglucinol-6,6'-bieckol 1621988-60-0 98%
    2,7"-Phloroglucinol-6,6'-bieckol is an orally active dual α-amylase/α-glucosidase inhibitor with IC50 values of 6.94 μM and 23.35 μM respectively. 2,7"-Phloroglucinol-6, 6'-bieckol alleviates postprandial hyperglycemia in diabetic mice. 2,7"-Phloroglucinol-6,6'-bieckol can be used in diabetes research.
    2,7
  • HY-N11736
    12-O-Tiglyl-phorbol 13-dodecanoate 37394-32-4 98%
    12-O-Tiglyl-phorbol 13-dodecanoate (TD13) is a potential inhibitor with anti-hepatic fibrosis activity, and it belongs to a series of derivatives of oral APOL2 inhibitors and anti-hepatic fibrosis agents. It shows no obvious toxicity in preclinical models. Compounds of the 12-O-Tiglyl-phorbol 13-dodecanoate series inhibit the expression of fibronectin, type I collagen and α-smooth muscle actin in hepatic stellate cells. 12-O-Tiglyl-phorbol 13-dodecanoate can be isolated from the Euphorbiaceae plant Euphorbia fischeriana, and it is applicable to the research of hepatic fibrosis.
    12-O-Tiglyl-phorbol 13-dodecanoate
  • HY-N11775
    Eudebeiolide B 1934299-51-0 98%
    Eudebeiolide B is a compound that can be isolated from Salvia plebeia R. Br. Eudebeiolide B inhibits osteoclastogenesis by regulating RANKL-induced NF-κB, c-Fos and calcium signaling. Eudebeiolide B can be used for osteoclast-related diseases research.
    Eudebeiolide B
  • HY-N11787
    Cimicifuga racemosa extract 84776-26-1 98%
    Cimicifuga racemosa extract is a herbal remedy with antiestrogenic properties found in the plant Cimicifuga racemosa, commonly used to alleviate menopausal symptoms and relieve symptoms such as hot flashes and night sweats.
    Cimicifuga racemosa extract
  • HY-N11812
    Erucifoline N-oxide 123864-94-8 98%
    Erucifoline N-oxide, a natural compound that can be isolated from Senecio persoonia, possesses hepatotoxic activity.
    Erucifoline N-oxide
  • HY-N11840
    Mortatarin F 98%
    Mortatarin F (Compound 1) is an inhibitor of α‑glucosidase with an IC50 of 8.7 μΜ. Mortatarin F is an renylated flavonoid that can be isolated from mulberry leaves and can be used for hypoglycemic research.
    Mortatarin F
  • HY-N11841
    Mortatarin G 2477746-26-0 98%
    Mortatarin G (compound 3) is a prenylated flavonoid, that can be isolated from mulberry leaves. Mortatarin G exhibits good α-glucosidase inhibitory activity, with an IC50 of 20.4±1.4 μM.
    Mortatarin G
  • HY-N11844
    Quercetin 3-(6″-caffeoylsophoroside) 1032595-77-9 98%
    Quercetin 3-(6″-caffeoylsophoroside) is an orally active α-amylase inhibitor, with an IC50 of 73.66 μg/mL. Quercetin 3-(6″-caffeoylsophoroside) presents in thehydro-methanolic extract of Cardamine hirsuta Linn. Quercetin 3-(6″-caffeoylsophoroside) shows the antidiabetic activities by oxidative stress reduction and α-amylase inhibition. Quercetin 3-(6″-caffeoylsophoroside) can be used for diabetes mellitus research.
    Quercetin 3-(6″-caffeoylsophoroside)
Cat. No. Product Name / Synonyms Application Reactivity